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LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA, Rowell N, Wollheim F: Scleroderma (systemic sclerosis): classification, subsets and pathogenesis

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NOX activity increases with aging, leading to excessive superoxide production and mitochondrial impairment, which worsens disease pathology 83

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